What is a partition coefficient? What is the relationship between a substance’s partition coefficient and its membrane permeability? Who did the early studies that demonstrated the relationship between membrane permeability and the partition coefficient?
What are two key differences between hexokinase and glucokinase?If a red blood cell has an internal osmolarity of 300 mOsm
- A) What is molarity of an iso-osmotic NaCl solution? What would be the molarity of an iso-osmotic CaCl2?
Note: f = 0.93 for NaCl and 0.86 for CaC
Outline how gut endothelial cells transport glucose from the gut lumen to the blood. Include all relevant transport mechanisms and the concentration gradients involved (is glucose going up or down its concentration gradient?
What was Gorter and Grendel’s contribution to our understanding of membrane structure? Outline their experiment that led to their model of membrane
What is the difference between a cofactor and a coenzyme? How are they similar?
Myoglobin (pictured below) is globular, oxygen-binding protein found in muscle and was the first protein whose structure was determined by x-ray crystallography. What level of protein organization does it represent? Label the levels of protein organization that can be seen in its structure.
Give a brief description of one positive feedback cycle ?
What are (the) 4:
- a) Key functions of cell membranes?
- b) Types of receptors used in cell-signaling
- c) Factors that influence enzyme reaction rate.
- d) Functional classes of proteins. (Note: Not primary, secondary, etc)
- e) Factors that influence the rate of diffusion of a molecule across a membrane.
Outline the feedback mechanism that regulates blood glucose homeostasis. (Don’t include the intracellular components.)
Give an example of a hydrolysis reaction discussed in class. What happens to the water molecule in the reaction? (4 pts)
What is the role of positive feedback in labor (childbirth)? (4 pts)
Briefly describe two key features of the Hippocratic Oath that are relevant to modern doctors. (4 pts)
The genetic code is a “triplet code.” Explain. (4 pts)
Enzymes lower the _______________ _________________ of a reaction.
A fever is an example of an altered _____________________.
Oxygen and carbon dioxide cross cell membranes by ___________ _____________.
Cystic fibrosis is caused by a defect in the ___________________ transport of __________________ ions in the cells of the lungs. The lack transport of the ions
across the lung membranes results in _____________________________ and thickened mucus..
A competitive inhibitor binds to the _________________ __________________ of an enzyme. The Km of glucose permease is 1.5 mM for glucose, but is 50 mM for galactose. This
indicates that the permease’s ___________________ for glucose is higher/lower (circle one!) than that for galactose.
One definition of ___________________ Law is: “The net diffusion rate of a solute across a membrane is proportional to the difference in the concentrations, proportional to the area of the membrane and inversely proportional to the thickness of the membrane.”
Na+/K+ ATPase belongs to the ______- class of ATPases, which means that
V-class ATPases carry out the ________________ transport of _______________ across membranes.
LDL and growth factors typically enter cells using _____________________________ .
The rate of passive transport is dependent upon the ____________________ of the solute and
_________________________.
A(n) ____________________________ is a collection of organs that work together to perform a major body function.
The sodium-potassium pump carries out the _______________________ transport of
_______(#) sodium ions into/out of (circle 1) the cell and __________(#) potassium ions into/out of (circle 1) the cell.
1 glycerol + 3 fatty acids = ____________________________________
The three phases of protein translation are ________________________________________
_________________________________________.
A sensor (receptor), ______________ _________________, and _______________________ are the key components of any feedback system.
The ______________ _______________ of an enzyme is where the substrate binds.
Osmosis is the movement of _______________ across a/an _____________________
membrane from an area of _______________ ________________concentration to an area
of _________________ ________________ concentration.
CH2O is the general formula for a/an ________________________________.
Amino acids are linked together via covalent bonds called ______________________ bonds.
Low-density lipoprotein (LDL) particles are transported into cells by ___________________
________________________ ________________________.
In “Anatomical Position” the legs and feet are ____________________________, the arms are
_________________________ and the palms are_____________________________________
Intermediate filaments, __________________________ and __________________________ are the key structures that make up the cytoskeleton.
The opposite of “ipsilateral” is ____________________________________.
The ability to maintain a stable internal environment even though the external environment changes is called ______________________________.
Globular and fibrous are classes of ____________________________.
Enzymes are organic catalysts that _______________________ the _________________ ________________________ (or energy barrier) of a reaction.
Physiology is the study of _________________________.
An organic catalyst of a reaction usually is a(n) ______________________.
A(n) ____________________________ is a collection of organs that work together to perform a major body function.
The ___________________________ separates the thoracic cavity from the abdominal cavity.
“K” is the chemical symbol for _______________________________.
The sodium-potassium pump carries out the _______________________ transport of
_______(#) sodium ions into/out of (circle 1) the cell and __________(#) potassium ions into/out of (circle 1) the cell.
1 glycerol + 3 fatty acids = ____________________________________
The ______________ _______________ of an enzyme is where the substrate binds.
Osmosis is the movement of _______________ across a/an _____________________
membrane from an area of ____________ _____________concentration to an area
of _________________ ________________ concentration.
A chromosome is the condensed form of _________________________.
Carbon dioxide gets through the cell membrane by ____________ ______________.
The folds of the inner membrane of mitochondria are called _______________.
In prophase, the ___________________ and ______________________ disappear and
_________________ migrate to opposite poles of the cell. These structures reform
during _______________________
CH2O is the general formula for a/an ________________________________.
Amino acids are linked together via covalent bonds called ______________________ bonds.
______________________ is the non-selective uptake of material, like water, from the extracellular environment.