Which of the following pregnant women has most likely encountered the greatest increase in the risk that her child will have a fetal anomaly?

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Which of the following pregnant women has most likely encountered the greatest increase in the risk that her child will have a fetal anomaly?
A woman with diagnoses of syphilis and cirrhosis of the liver
A woman who has herpes simplex and recently recovered from endocarditis
A woman with chronic obstructive pulmonary syndrome and tuberculosis
A woman with diagnoses of insulin-dependent diabetes mellitus and peripheral neuropathy

 
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