Question 1 Mismatch repair requires ___ enzymatic activity. Endonuclease DNA Polymerase Ligase All of the above 0.

Question 1

1. Mismatch repair requires ___ enzymatic activity.
2. Endonuclease
3. DNA Polymerase
4. Ligase
5. All of the above

0.5 points  

Question 2

1. Pyrimidine dimers that are detected by the cell are most likely to be repaired using:
2. Mismatch repair
3. Proofreading
4. Excision repair

0.5 points  

Question 3

1. Conversion of C to G in DNA is an example of a:
2. Tautomerization
3. Transversion
4. Transition
5. Pyrimidine dimer

0.5 points  

Question 4

1. Shown below is a diagram of a eukaryotic replication bubble with only the template shown. Where on the diagram is the leading strand? (Examine the template DNA very carefully before answering this question!)
2. A
3. B
4. C
5. D

0.5 points  

Question 5

1. Shown below is a diagram of a eukaryotic replication bubble with only the template shown. Where is the lagging strand? (Examine the template DNA very carefully before answering this question!)
2. A
3. B
4. C
5. D

0.5 points  

Question 6

1. Shown below is a diagram of a eukaryotic replication bubble with only the template shown. Where is the lagging strand? (Examine the template DNA very carefully before answering this question!)
2. A
3. B
4. C
5. D

0.5 points  

Question 7

1. What problem is caused by the formation of Okazaki fragments and what is the cell’s solution?
2. They result in excessive twisting of the DNA, which is relieved by Topoisomerase.
3. They are short, discontinuous stretches of DNA, which must be annealed using Ligase.
4. They require DNA synthesis to occur in the 3′ to 5′ direction, which is catalyzed by Primase.

0.5 points  

Question 8

1. What kind of enzyme catalyzes polymerization of DNA?
2. Endonuclease
3. Polymerase
4. Primase
5. Helicase

0.5 points  

Question 9

1. What problem associated with DNA replication is solved by the formation of Okazaki fragments?
2. DNA replication begins at multiple origins of replication in eukaryotes.
3. The two strands of DNA are held together by millions of hydrogen bonds, making separation extremely difficult.
4. DNA must polymerize in the 5′ to 3′ direction on a template.
5. DNA polymerization requires an existing chain onto which to add new dNTPs.

0.5 points  

Question 10

1. What would you observe in a cell in which DNA helicase was inactivated?
2. DNA replication would fail due to the inability to separate the two strands of DNA.
3. DNA replication would fail due to the absence of a primer for DNA polymerization.
4. DNA replication would begin, but would eventually stall due to the increase in twisting beyond the replication fork.
5. DNA replication would occur on the leading strand, but not the lagging strand.

 

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